cancer biology
Reproducibility: The New Frontier in AI Governance
Mason-Williams, Israel, Mason-Williams, Gabryel
AI policymakers are responsible for delivering effective governance mechanisms that can provide safe, aligned and trustworthy AI development. However, the information environment offered to policymakers is characterised by an unnecessarily low Signal-To-Noise Ratio, favouring regulatory capture and creating deep uncertainty and divides on which risks should be prioritised from a governance perspective. We posit that the current publication speeds in AI combined with the lack of strong scientific standards, via weak reproducibility protocols, effectively erodes the power of policymakers to enact meaningful policy and governance protocols. Our paper outlines how AI research could adopt stricter reproducibility guidelines to assist governance endeavours and improve consensus on the AI risk landscape. We evaluate the forthcoming reproducibility crisis within AI research through the lens of crises in other scientific domains; providing a commentary on how adopting preregistration, increased statistical power and negative result publication reproducibility protocols can enable effective AI governance. While we maintain that AI governance must be reactive due to AI's significant societal implications we argue that policymakers and governments must consider reproducibility protocols as a core tool in the governance arsenal and demand higher standards for AI research. Code to replicate data and figures: https://github.com/IFMW01/reproducibility-the-new-frontier-in-ai-governance
Localized Data Fusion for Kernel k-Means Clustering with Application to Cancer Biology
In many modern applications from, for example, bioinformatics and computer vision, samples have multiple feature representations coming from different data sources. Multiview learning algorithms try to exploit all these available information to obtain a better learner in such scenarios. In this paper, we propose a novel multiple kernel learning algorithm that extends kernel k-means clustering to the multiview setting, which combines kernels calculated on the views in a localized way to better capture sample-specific characteristics of the data. We demonstrate the better performance of our localized data fusion approach on a human colon and rectal cancer data set by clustering patients. Our method finds more relevant prognostic patient groups than global data fusion methods when we evaluate the results with respect to three commonly used clinical biomarkers.
Localized Data Fusion for Kernel k-Means Clustering with Application to Cancer Biology
Gönen, Mehmet, Margolin, Adam A.
In many modern applications from, for example, bioinformatics and computer vision, samples have multiple feature representations coming from different data sources. Multiview learning algorithms try to exploit all these available information to obtain a better learner in such scenarios. In this paper, we propose a novel multiple kernel learning algorithm that extends kernel k-means clustering to the multiview setting, which combines kernels calculated on the views in a localized way to better capture sample-specific characteristics of the data. We demonstrate the better performance of our localized data fusion approach on a human colon and rectal cancer data set by clustering patients. Our method finds more relevant prognostic patient groups than global data fusion methods when we evaluate the results with respect to three commonly used clinical biomarkers.